Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 3-hydroxyisobutyrate or methacrylic acid related thereto
US9346902B2 · kind B2 · utility
4Cited by
3References
18Claims
0Family size
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Key dates
| Filing date | Nov 4, 2013 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Nov 4, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y201/0109
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.