Methods to improve vector expression and genetic stability
US9347065B2 · kind B2 · utility
5Cited by
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4Claims
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Key dates
| Filing date | Mar 10, 2013 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Mar 10, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20243
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.