Single-protein nanomechanical mass spectrometry in real time
US9347815B2 · kind B2 · utility
6Cited by
12References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 8, 2013 |
| Grant date | May 24, 2016 |
| Priority date | — |
| Expiry date | Dec 21, 2034 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/34
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.