Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
US9351989B2 · kind B2 · utility
12Cited by
35References
7Claims
0Family size
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Key dates
| Filing date | Dec 29, 2011 |
| Grant date | May 31, 2016 |
| Priority date | — |
| Expiry date | Sep 11, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/067
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to phosphoroamidate and phosphorodiamidate derivatives including the compounds of formula (I) having the structurewherein U, V, W, Z, R1, X1, X2, and Y are defined herein. These compounds and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals infected by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV). The compounds of this invention may be prepared by various methods known in the art of organic chemistry in general and nucleoside and nucleotide analog synthesis in particular.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.