Systems, compositions, and methods for transplantation and treating conditions
US9352021B2 · kind B2 · utility
13Cited by
62References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 2014 |
| Grant date | May 31, 2016 |
| Priority date | — |
| Expiry date | Aug 28, 2034 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2325/0283
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.