Nanoparticle-insulin and insulin analogue compositions
US9352026B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 2015 |
| Grant date | May 31, 2016 |
| Priority date | — |
| Expiry date | Jan 29, 2035 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB65D25/205
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to insulin- and insulin analog-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analog, such as a rapidly-acting insulin analog. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analog, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analog peptide that is non-covalently bound to the corona.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.