Trialkyl cationic lipids and methods of use thereof
US9352042B2 · kind B2 · utility
99Cited by
4References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 22, 2013 |
| Grant date | May 31, 2016 |
| Priority date | — |
| Expiry date | Mar 18, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.