Zwitterionic reagents

US9353056B2 · kind B2 · utility

Assignee

• Siemens Healthcare Diagnostics Inc. · US

Inventors

• Anand Natrajan · Manchester, US
• David Sharpe · Foxborough, US
• David Wen · Northborough, US
• Qingping Jiang · Northborough, US

Key dates

• Filing date: May 18, 2011
• Grant date: May 31, 2016
• Expiry date: May 15, 2032

Classification

• Technology area (CPC —): General

Abstract

Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.