Methods of preparation of conjugates
US9353127B2 · kind B2 · utility
18Cited by
7References
69Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 15, 2012 |
| Grant date | May 31, 2016 |
| Priority date | — |
| Expiry date | Jun 28, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.