Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment

US9353150B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Board of Trustees of the University of Illinois · US

Inventors

• Mohammad Movassaghi · Lincoln, US
• Justin Kim · Burbank, US
• Paul J. Hergenrother · Champaign, US
• Karen Morrison · Champaign, US
• Nicolas Cedric Boyer · Somerville, US

Key dates

• Filing date: Dec 4, 2013
• Grant date: May 31, 2016
• Expiry date: Jan 30, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides, among other things, a compound of Formula I-a and/or I-b,or a pharmaceutically acceptable salt thereof, wherein the variables are defined in the specification. The compounds of the invention are useful for treating various diseases including cancer.