Biologically active molecules for influencing virus-, bacteria-, parasite-infected cells and/or tumor cells and method for the use thereof

US9353369B2 · kind B2 · utility

Assignee

• UNIVERSITÄTSKLINIKUM JENA · DE

Inventors

• Tobias Poehlmann · Zwickau, DE
• Rolf GUENTHER · Aachen, DE

Key dates

• Filing date: Jan 11, 2011
• Grant date: May 31, 2016
• Expiry date: Apr 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The aim of the invention is to effectively inhibit virus-, bacteria-, or parasite-infected cells and tumor cells in a targeted manner, even in the case of mutations. According to the invention, biologically active molecules are administered, said biologically active molecules including at least one protease inhibitor for at least one specific target protease of the virus-, bacteria-, or parasite-infected cells and/or tumor cells and at least one peptide-inhibited siRNA, PNA or RNA, the peptide bond of which is broken by the at least one target protease for the purpose of activating the peptide-inhibited siRNA, PNA or RNA. The molecules are used, for example, to influence the gene expression of diseased and infected organs or cells.