Methods of treatment with drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations

US9358096B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Kent C. B. Stalker · San Marcos, US
• Winnette S. McIntosh · San Jose, US
• Dudley Jayasinghe · Pittsburg, US
• Gregory C. Orr · Oceanside, US
• John E. Papp · Anaheim, US
• Lewis B. Schwartz · Lake Forest, US

Key dates

• Filing date: Jun 3, 2013
• Grant date: Jun 7, 2016
• Expiry date: Jun 3, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2420/08
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 μg/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.