Method of treating constipation

US9358245B2 · kind B2 · utility

Assignee

• Cedars Sinai Medical Center · US

Inventors

• Mark Pimentel · Los Angeles, US
• Henry Lin · Hsinchu, TW

Key dates

• Filing date: Apr 16, 2014
• Grant date: Jun 7, 2016
• Expiry date: Apr 16, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N1/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method of manipulating the rate of gastrointestinal transit in a mammalian subject. Also disclosed is the use, in the manufacture of a medicament for the treatment of constipation, of a selective inhibitor of methanogensis, a methanogen-displacing probiotic agent, or a prebiotic agent that inhibits the growth of methanogenic bacteria or promotes the growth of competing non-methanogenic intestinal flora. Alternatively, in accordance with the invention, is disclosed the use in the manufacture of a medicament for the treatment of diarrhea, of methane or a methane precursor, a methanogenic or other methane-enhancing probiotic agent, or a methanogenesis-enhancing prebiotic agent.