Lipid therapy

US9358268B2 · kind B2 · utility

Assignee

• Abbott Cardiovascular Systems, Inc. · US

Inventors

• Deborah Kilpatrick · Mountain View, US
• Syed Faiyaz Ahmed Hossainy · Fremont, US
• Irina Astafieva · Palo Alto, US
• Florian N. Ludwig · Mountain View, US
• Paul Consigny · San Jose, US
• Jeffrey T. Ellis · Mountain View, US
• Florencia Lim · Union City, US

Key dates

• Filing date: Jun 9, 2014
• Grant date: Jun 7, 2016
• Expiry date: Jun 9, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2202/0456
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.