Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates
US9359333B2 · kind B2 · utility
0Cited by
3References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 21, 2015 |
| Grant date | Jun 7, 2016 |
| Priority date | — |
| Expiry date | Jul 21, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof.In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.