Protein disulfide isomerase inhibiting anticancer agents
US9359342B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Nov 10, 2014 |
| Grant date | Jun 7, 2016 |
| Priority date | — |
| Expiry date | Nov 10, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Protein disulfide isomerase inhibitors according to formula Iare described, wherein R1 is an aryl or cycloalkyl group, R2 is selected from the group consisting of CN, SO2CH3, NO2, CO2R3, CONHR3, NMe2, and CF3, R3 is selected from H or lower alkyl, R4 is H, halogen, CN, or COOH, and X and Y are C—H or heteroatoms selected from the group consisting of N, O, and S. The protein disulfide isomerase inhibitors can be used for the treatment of cancer in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.