Inhibitors of Akt/PKB with anti-tumor activity
US9359347B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 2012 |
| Grant date | Jun 7, 2016 |
| Priority date | — |
| Expiry date | Nov 4, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/23
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering an effective amount of a compound of formula I to the person or animal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.