Method for manufacturing protein drug
US9359397B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 2012 |
| Grant date | Jun 7, 2016 |
| Priority date | — |
| Expiry date | Jun 22, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention provides a method for manufacturing a virus-free protein drug, comprising (a) a filtration step of filtering a virus-containing protein solution through a small-pore size virus removal membrane to obtain a virus-free protein solution, the filtration step (a) comprising (q) a low-pressure filtration step of filtering the solution through the small-pore size virus removal membrane at a filtration pressure of 0.30 kgf/cm2 or lower to obtain the virus-free protein solution, wherein the solution prior to filtration in the low-pressure filtration step (q) has a pH (X) and a salt ionic strength (Y (mM)) that satisfy the following equations 1 and 5: 0≦Y≦150X−590 (Equation 1) and 3.5≦X≦8.0 (Equation 5) or the following equations 4 and 5: Y=0 (Equation 4) and 3.5≦X≦8.0 (Equation 5).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.