Single chain trail fusion polypeptides and encoding nucleic acids

US9359420B2 · kind B2 · utility

Assignee

• APOGENIX AG · DE

Inventors

• Oliver Hill · Neckarsteinach, DE
• Christian Gieffers · Dossenheim, DE
• Meinolf Thiemann · Schriesheim, DE

Key dates

• Filing date: Jun 30, 2014
• Grant date: Jun 7, 2016
• Expiry date: Jun 30, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.