Patent · US Active

Antibodies comprising chimeric constant domains

US9359437B2 · kind B2 · utility

36Cited by

19References

21Claims

0Family size

Assignee

REGENERON PHARMACEUTICALS, INC. · US

Inventors

Samuel Davis · New York, US
Eric Smith · New York, US
Supriya Patel · Mamaroneck, US

Key dates

Filing date	Jan 31, 2014
Grant date	Jun 7, 2016
Priority date	—
Expiry date	May 29, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.