Antibody to a carbonic anhydrase

US9359446B2 · kind B2 · utility

Assignee

• Hemholtz Zentrum Munchen—Deutches Forschungszentrum Fur Gesundheit Und Umwelt (GmbH) · DE

Inventors

• Reinhard Zeidler · Birkenfeld, DE
• Christina Battke · Unterhaching, DE
• Elisabeth Kremmer · Freising, DE
• Andrew Flatley · Weßling, DE
• Claudiu Supuran · Firenze, IT

Key dates

• Filing date: May 2, 2011
• Grant date: Jun 7, 2016
• Expiry date: Aug 27, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an antibody binding to a carbonic anhydrase, wherein the antibody comprises (a) the amino acid sequences SEQ ID NOS. 1 (CDR 1), 2 (CDR 2) and 3 (CDR 3) determining the CDRs of the VH region, and the amino acid sequences SEQ ID NOS. 4 (CDR 1), 5 (CDR 2) and 6 (CDR 3) determining the CDRs of the VL region; or (b) the amino acids sequences of (a), wherein at least one amino acid is conservatively substituted in any one of the amino acid sequences SEQ ID NOS. 1 to 6.