3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma

US9364459B2 · kind B2 · utility

Assignees

• Johannes Gutenberg-Universität Mainz · DE
• Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Gerd Dannhardt · Mainz, DE
• Stanislav Plutizki · Mainz, DE
• Jan-Peter Kramb · Mainz, DE
• Annett Müller · Griesheim, DE
• Markus Möhler · Mainz, DE

Key dates

• Filing date: Dec 10, 2010
• Grant date: Jun 14, 2016
• Expiry date: Dec 10, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of a compound of formula (I) wherein R1 and R3 are as defined in the description and R2 is a phenyl group which is substituted with 2 or 3 C1-C6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for treatment of colorectal or gastric adenocarcinoma.