Methods and compositions for enhancing the uptake of therapeutic agents by target cells
US9364493B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 28, 2012 |
| Grant date | Jun 14, 2016 |
| Priority date | — |
| Expiry date | Mar 28, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.