Compositions and methods for promoting hemostasis and other physiological activities

US9364513B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• Versitech Limited · CN

Inventors

• Rutledge Ellis-Behnke · Canton, US
• Shuguang Zhang · Lexington, US
• Gerald Schneider · Somerville, US
• Kwok-Fai So · Hong Kong, CN
• David Tay · Hong Kong, CN
• Yu-Xiang Liang · Hong Kong, CN

Key dates

• Filing date: Aug 27, 2008
• Grant date: Jun 14, 2016
• Expiry date: Aug 27, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.