Pederin and psymberin agents

US9364555B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Paul E. Floreancig · Pittsburgh, US
• Billy W. Day · Pittsburgh, US
• Shuangyi Wan
• Fanghui Wu · Pittsburgh, US

Key dates

• Filing date: Jul 19, 2012
• Grant date: Jun 14, 2016
• Expiry date: Jul 19, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D407/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold includes a substituent at the C8 and/or C11 positions that may include a linker that may be conjugated to a targeting moiety. The pederin/psymberin chimera scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The pederin, psymberin or pederin/psymberin chimera scaffold may be modified to include substituents at positions other than the C10 or C13 of pederin, or the C8 and C11 of psymberin.