Ultrasound contrast agents and process for the preparation thereof
US9364569B2 · kind B2 · utility
6Cited by
39References
57Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 3, 2004 |
| Grant date | Jun 14, 2016 |
| Priority date | — |
| Expiry date | Nov 1, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.