Salts of kukoamine B, preparation method and use thereof

US9365504B2 · kind B2 · utility

Assignees

• THE FIRST AFFILIATED HOSPITAL, THIRD MILITARY UNIVERSITY, PLA · CN
• TIANJIN CHASE SUN PHARMACEUTICAL CO. LTD · CN

Inventors

• Jiang Zheng · Chongqing, CN
• Xinchuan Zheng · Chongqing, CN
• Xin Liu · Hubei, CN
• Hong Zhou · Hangzhou City, CN
• Ning Wang · 红钢城街道, CN
• Hongwei Cao · Chongqing, CN
• Yan Li · Xi'an, CN
• Yongling Lu · 安丰镇, CN
• Kecen Zhao · Chongqing, CN
• Jingcheng Yang · Chongqing, CN
• Yang Yang · Parsippany, US
• Yuanfeng Zhu · Nanchang, CN
• Guo Wei · Beijing, CN
• Min Huang · Chongqing, CN

Key dates

• Filing date: Mar 21, 2011
• Grant date: Jun 14, 2016
• Expiry date: Mar 16, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C309/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.