Imidazolyl amide compounds and uses related thereto

US9365523B2 · kind B2 · utility

Assignees

• EMORY UNIVERSITY · US
• Children's Healthcare of Atlanta · US

Inventors

• Richard K. Plemper · Decatur, US
• James P. Snyder · Atlanta, US
• Aiming Sun · Atlanta, US
• John Ndungu · West Palm Beach, US
• Jeong-Joong Yoon · Decatur, US

Key dates

• Filing date: Mar 28, 2012
• Grant date: Jun 14, 2016
• Expiry date: Mar 28, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising 2-((benzo[d]imidazol-2-yl)thio)-N-phenylpropanamide derivatives, N-phenyl-2-((1-phenyl-benzo[d]imidazol-2-yl)thio)propanamide derivatives, or 2-((benzo[d]imidazol-2-yl)thio)-N-(2-chloro-4-methylphenyl)propanamide derivatives. The derivatives may be substituted with one or more substituents. Typically, the pharmaceutical composition comprises a compound of Formula (I), or salt, prodrug, or ester thereof wherein X, Y, and R1 to R7 are described herein.