Salts of aza-bicyclic di-aryl ethers and pharmaceuticals thereof

US9365565B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Wolfgang Marterer · Bad Krozingen, DE
• Mahavir Prashad · East Hanover, US
• Edwin Bernard Villhauer · Morristown, US
• Liladhar Murlidhar Waykole · East Hanover, US
• James Anthony Vivelo · Berkeley Heights, US
• Bertrand Sutter · Basel, CH
• Jean-Claude Bianchi · Blotzheim, FR
• Raeann Wu · Montville, US
• Denis Har · East Hanover, US
• Piotr H. Karpinski · Lincoln Park, US
• Massimo Pignone · Basel, CH
• Doris Stingelin · Basel, CH
• Eckart Buerger · Köniz, CH

Key dates

• Filing date: Jul 12, 2012
• Grant date: Jun 14, 2016
• Expiry date: Jul 12, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.