Cinnoline derivatives

US9365566B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• John David Lawson · San Diego, US
• Mark Sabat · Loveland, US
• Christopher Ronald Smith · San Diego, US
• Haixia Wang · San Diego, US
• Young K. Chen · San Marcos, US
• Toufike Kanouni · Rancho Santa Fe, US

Key dates

• Filing date: Mar 25, 2013
• Grant date: Jun 14, 2016
• Expiry date: Mar 25, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula 1,and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined in the specification. The compounds are inhibitors of Bruton's tyrosine kinase (BTK). This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders or conditions associated with BTK.