Caspase inhibitors

US9365612B2 · kind B2 · utility

Assignee

• UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · US

Inventors

• Craig J. Thomas · Gaithersburg, US
• Matthew B. Boxer · Point of Rocks, US

Key dates

• Filing date: Jan 27, 2011
• Grant date: Jun 14, 2016
• Expiry date: Jan 29, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06191
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound, or a pharmaceutically acceptable salt or ester thereof, of formula I:X—Wwherein X is a caspase-selective structure and W has the structure of—NH—CH(Y)(Z)wherein Y is a structure that can form a reversible covalent bond with a caspase; andZ is selected from a carboxyl moiety or a carboxylic acid mimetic.