Designed armadillo repeat proteins
US9365629B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 23, 2008 |
| Grant date | Jun 14, 2016 |
| Priority date | — |
| Expiry date | Apr 21, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1044
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.