Spectroscopic means and methods for identifying microorganisms in culture
US9365883B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2012 |
| Grant date | Jun 14, 2016 |
| Priority date | — |
| Expiry date | Feb 20, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B99/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A spectroscopic method for spectroscopic detection and identification of bacteria in culture is disclosed. The method incorporates construction of at least one data set, which may be a spectrum, interference pattern, or scattering pattern, from a cultured sample suspected of containing said bacteria. The data set is corrected for the presence of water in the sample, spectral features are extracted using a principal components analysis, and the features are classified using a learning algorithm. In some embodiments of the invention, for example, to differentiate MRSA from MSSA, a multimodal analysis is performed in which identification of the bacteria is made based on a spectrum of the sample, an interference pattern used to determine cell wall thickness, and a scattering pattern used to determine cell wall roughness. An apparatus for performing the method is also disclosed, one embodiment of which incorporates a multiple sample analyzer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.