Protective effects of curcumin against hemorrhagic stroke injury

US9371263B2 · kind B2 · utility

Assignees

• Augusta University Research Institute, Inc. · US
• EAST CHINA NORMAL UNIVERSITY · CN

Inventors

• Cargill H. Alleyne, Jr. · Martinez, US
• Krishnan M. DHANDAPANI · Statesboro, US
• Ken WEN · Beijing, CN
• MingLiang Ma · Shanghai, CN
• Wenjing Hu · Lo Wu, CN

Key dates

• Filing date: Sep 22, 2014
• Grant date: Jun 21, 2016
• Expiry date: Sep 22, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/738
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds, compositions and methods for preventing and treating diseases such as intracerebral hemorrhage, cancer, or conditions associated with damaged cells, activated lymphocytes, or microbial products. The disclosed compounds are curcumin analogs. The curcumin analogs possess anti-inflammatory and antioxidant properties, which in part, reduce AP-1 and NF-κB activity.