Method for manufacturing tertiary amino group-containing lipid
US9371271B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 2013 |
| Grant date | Jun 21, 2016 |
| Priority date | — |
| Expiry date | Jun 21, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from a cis form to a trans form is suppressed.A compound represented by the following formula (I):R1—X (I)(in Formula, R1 represents a hydrocarbon group having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule and having the carbon number of 8 to 24 and X represents a releasing group) is reacted with (B) a compound having at least one of each of tertiary amino group and hydroxyl group in the molecule in a saturated hydrocarbon solvent having the carbon number of 5 to 10 in the presence of an alkali catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.