Patent · US Active

Quinazoline derivative, preparation method therefor, intermediate, composition and application thereof

US9371292B2 · kind B2 · utility

0Cited by

1References

4Claims

0Family size

Assignees

Shanghai Pharmaceuticals Holding Co., Ltd. · CN
ZHEJIANG UNIVERSITY · CN

Inventors

Guangxin Xia · Shanghai, CN
Jingkang Shen · Shanghai, CN
Yongping Yu · Hangzhou City, CN
Wenteng Chen · Hangzhou City, CN
Chunchun Zhang · North Potomac, US
Yu Hao · Shanghai, CN
Jing Zhang · Wantage, US
Bojun Li · Shanghai, CN
Xuejun Liu · Shanghai, CN

Key dates

Filing date	Jul 27, 2012
Grant date	Jun 21, 2016
Priority date	—
Expiry date	Aug 8, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed are as represented by Formula (I) a quinazoline derivative and a pharmaceutical acceptable salt thereof, or, an enantiomer, a non-enantiomer, a tautomer, a racemate, a solvate, a metabolic precursor, or a prodrug of both. Also disclosed are a preparation method therefor, an intermediate, a pharmaceutical composition having the quinazoline derivative, and an application thereof. The quinazoline derivative of the present invention is provided with improved anti-tumor activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.