Method for synthesizing sapropterin dihydrochloride
US9371326B2 · kind B2 · utility
0Cited by
0References
9Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 27, 2012 |
| Grant date | Jun 21, 2016 |
| Priority date | — |
| Expiry date | Dec 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, and resolves a racemate intermediate or an intermediate having a low antimer isomerism value by using a chiral resolving reagent, thereby obtaining an intermediate having a high antimer isomerism value. Raw materials are cheap and readily available, and the cost is significantly reduced, hence providing an effective scheme for mass industrial production of the sapropterin dihydrochloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.