Chromene derivatives and their analoga as Wnt pathway antagonists

US9371333B2 · kind B2 · utility

Assignees

• Deutsches Krebsforschungszentrum · DE
• RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

• Michael Boutros · Heidelberg, DE
• Rajendra-Prasad Maskey · Heidelberg, DE
• Corinna Koch · Lorsch, DE
• Florian Fuchs · Weil am Rhein, DE
• Sandra Steinbrink · Eppstein, DE
• Daniel Gilbert · Koblenzer Straße, DE

Key dates

• Filing date: Nov 11, 2011
• Grant date: Jun 21, 2016
• Expiry date: Nov 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.