Composition comprising gas-filled microcapsules for ultrasound mediated delivery
US9375397B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 28, 2011 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Apr 28, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/0008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.