Compounds that treat malaria and prevent malaria transmission

US9375424B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary, Dept. of Health and Human Services · US

Inventors

• Xin Su · Beijing, CN
• Jing Yuan · Lansdale, US
• Dipak Kumar Raj · Central Falls, US
• Sittiporn Pattaradilokrat · Rockville, US
• Ron J. Johnson · Novi, US
• Ruili Huang · Rockville, US

Key dates

• Filing date: Aug 27, 2010
• Grant date: Jun 28, 2016
• Expiry date: Feb 8, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and compounds for the treatment and prevention of malaria infection and transmission in a mammal by administering compounds of the invention to a mammal having or suspected of having a malaria infection. The invention also provides pharmaceutical compositions that can kill or arrest the growth of Plasmodium organisms, and especially Plasmodium falciparum, thereby preventing or blocking transmission of malaria as well as treating malaria infection.