High penetration prodrug compositions of peptides and peptide-related compounds
US9376381B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 8, 2009 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Feb 7, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0014
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of peptides and peptide-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.