Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
US9376461B2 · kind B2 · utility
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Key dates
| Filing date | Jun 6, 2012 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Aug 9, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.