Proteolytically resistant hydrogen bond surrogate helices
US9376469B2 · kind B2 · utility
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3References
27Claims
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Key dates
| Filing date | Dec 21, 2012 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Jan 19, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to peptidomimetics having a stable, internally constrained protein secondary structure, where the peptidomimetics contain a hydrogen bond surrogate in the internal constraint, and at least one beta amino acid. Methods for promoting cell death using peptidomimetics that inhibit p53/hDM2 are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.