Antibodies directed against ICOS and uses thereof
US9376493B2 · kind B2 · utility
22Cited by
1References
4Claims
0Family size
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Key dates
| Filing date | Mar 29, 2012 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Oct 1, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.