Protease detection
US9376706B2 · kind B2 · utility
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2References
7Claims
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Assignee
Inventor
Key dates
| Filing date | Nov 25, 2014 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Nov 25, 2034 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0809
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A polypeptide comprising a chromogenic amino acid. The chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof. The amine group of the chromogenic amino acid has a pKa of less than 5. The chromogenic amino acid is capable of reacting with a conjugated aldehyde. The polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.