Image registration, averaging, and compounding for high speed extended depth optical coherence tomography

US9377291B2 · kind B2 · utility

Assignee

• Bioptigen, Inc. · US

Inventors

• Eric L. Buckland · Hickory, US
• Al-Hafeez Dhalla · Durham, US
• Nestor O. Farmiga · Rochester, US
• Mehran Ghofrani · Cary, US
• Robert H. Hart · Cary, US
• Andrew Murnan · Saratoga Springs, US
• Christopher Saxer · Cary, US

Key dates

• Filing date: Dec 5, 2014
• Grant date: Jun 28, 2016
• Expiry date: Jan 12, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01B9/02091
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflector at a first reference optical path length and a second path having a second reference reflector at a second reference optical path length, different from the first reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflector during a first time interval and the second reference reflector during a second time interval. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms; multiples the first preconditioned wavelength dependent interferogram and the second preconditio…