Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
US9377454B2 · kind B2 · utility
25Cited by
17References
6Claims
0Family size
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Key dates
| Filing date | Jun 25, 2010 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Jun 25, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response during intravenous PEGylated uricase therapy in gout patients is provided. Routine SUA monitoring can be used to identify patients receiving PEGylated uricase who may no longer benefit from treatment and who are at greater risk for infusion reactions.
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