Methods and compositions for the treatment of β-thalassemia
US9377471B2 · kind B2 · utility
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Key dates
| Filing date | Nov 19, 2014 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Nov 27, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.