Nano-recombinant fibrinogen for fibrin sealants
US9381232B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Nov 24, 2014 |
| Grant date | Jul 5, 2016 |
| Priority date | — |
| Expiry date | Feb 21, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, and (ii) coiled-coils of recombinantly-produced human fibrinogen α and chains and the γ chain globular domain. A delivery system for the hemostatic agent also is disclosed, which additionally comprises means for delivering (i) and (ii) to a wound site. The delivery means may be a CO2 canister or a shaker jet.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.