Patent · US Active

Heterocyclic and cyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase

US9382213B2 · kind B2 · utility

0Cited by

3References

24Claims

0Family size

Assignees

PROMILIAD BIOPHARMA INC. · US
UNIVERSITY OF CONNECTICUT · US

Inventors

Dennis L. Wright · Farmington, US
Amy C. Anderson
Grant Sormunen · Athens, US

Key dates

Filing date	Feb 12, 2015
Grant date	Jul 5, 2016
Priority date	—
Expiry date	Feb 12, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds of Formula I and Formula IA are inhibitors of dihydrofolate reductase and are suitable for use in compositions and methods for dihydrofolate reductase inhibition or, more specifically, treatment of a fungal infection, a bacterial infection or a protozoal infection, and, in specific embodiments, treatment of a fungal infection caused by C. albicans or C. glabrata:wherein R, R1, R2, R3, R4, A, B, E, V, W, X, Y and Z are as defined herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.